Bio-Oligo Nucleic Acid Synthesizers (Laboratory, Pilot and Process scale)

Bio-Oligo is a models’ line of preparative oligonucleotides synthesizers, available in different configurations for synthesis scale from 1 umol to 60mmol.

Bio-Oligo systems can synthesize 1 μmol – 60 mmol of DNA/RNA. Synthesizer devices utilize modular design, intelligent software and could be combined with synthesis columns of different size. The systems are fully automated, GLP/GMP compliance and could be used in R&D and industrial scale facilities for oligo-based drugs and IVD arrays development and production.

 

Main features:

  • Biocompatibility: stacked piping design, small dead volume, piping resistant to conventional organic solvents; 
  • High flow accuracy: PEEK material dual pump head with high flow accuracy control and pump head self-cleaning function; 
  • ​Multi user management: multi-user login and management, ensure information security and tracking;
  • ​Custom method editing: process
  • parameters setting module customization, process method self-editing;
  • ​High degree of automation: low reagent loss, monitoring of synthesis pressure, conductivity and UV detection;
  • High synthesis efficiency: > 99% for DNA, > 98% for RNA;
  • Individually customized: base monomer and synthesis reagents channels quantity by customer’s needs;
  • Compliance with laws and regulations: Software complies the regulations such as 21 CFR Part 11, explosion-proof design

Specifications

Bio-Oligo Lab 10 Bio-Oligo Lab 100 Bio-Oligo Pro 400
Synthesis scale 1 μmol – 50 μmol 50 μmol – 9 mmol 4 mmol – 60 mmol
System pump Binary piston pump, PEEK; Pump head self-washing function Binary piston pump, stainless steel; Pump head self-washing function
Flow rate 0.01 – 10 ml/min 0.01 – 100 ml/min Up to 600 ml/min
Operating pressure Up to 15 bar
Inert gas pressure 0.3~0.35 bar (Nitrogen/Argon)
Optical detector 1-channel 190-400 nm detector; other types are available as option 4-channel 200-800 nm detector 
Conductivity probe 1~999 mS/cm detection range, with integrated temperature probe
Base, reagents inlets and outlets (standard), 

more available as option

Base – 8

Reagents – 8 

Outlets – 6

Base – 11

Reagents – 9 

Outlets – 8

Synthesis channels (Reaction columns) q-ty,

more available as option

1-5 1
PC and Software Control PC and Bio-Oligo software

 

Resources

Ordering Information

Models (systems and reaction columns)
Bio-Oligo Lab 10 system 1 unit
Bio-Oligo Lab 100 system 1 unit
Bio-Oligo Pro 400 system 1 unit
SYC 1.2 (1.2 ml SS column) 1 unit
SYC 6.3 (6.3 ml SS column) 1 unit
SYC 12 (12 ml SS column) 1 unit
SYC 24 (24 ml SS column) 1 unit
SYC 48 (48 ml SS column) 1 unit
SYC 35 (Glass column, 35×150 mm, adjustable volume) 1 unit
SYC 60 (SS column, 60 mm id, different length available, adjustable volume) 1 unit
SYC 100 (SS column, 100 mm id, different length available, adjustable volume) 1 unit
SYC 150 (SS column, 150 mm id, different length available, adjustable volume) 1 unit
SYC 600 (SS column, 600 mm id, different length available, adjustable volume) 1 unit
All the models should be configured in accordance with technical requirements. 

Please contact us for further discussion.

 

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