Benchtop Fermenters and Bioreactors System

In Touch with Biotechnology

• Design for easy use and maintenance.
• Apply various functions to enable multi-purpose culture experiments
• User-friendly control display configuration.

Main features are:

• Compact design for various culture experiments even in a small space laboratory
• Apply self-diagnosis system that can record and maintain fermentation process, record and control it in real time
• Configured to enable DO Cascade (dissolved oxygen automatic control) so that various culture experiments are possible.
• Control by easily connecting an external device to the fermenter controller (O₂/CO₂ analyzer, gas mixer, scale, level sensor, external pump, analog printer, etc.)
• Manage all data by configuring a multi-channel network through one PC monitor

Available models: BIOCANVAS LF, BIOTWINstation, BIOCANVAS LF Plus

BIOCANVAS LF and BIOCANVAS LF Plus

Fermenter and Bioreactor Vessel can be customized according to user’s requirements.

Integrated control of 1 to 6 units using a PC control Program

BIOTWINstation

• Single and multi-channel setting to control one or more culture vessels
• Control up to 8CH by one screen
• Secure space by reducing installation space
• Apply 15.6” touch screen applied
• Able to use various vessels ranging from 1L to 13L

• Unfeed newborn calves within 14 hours of birth
• 3 times filtered with 0.1um to remove bacteria, tested for comprehensive physical, chemical, microbiological indicators.
•  Pure domestic newborn bovine serum raw material, better than imported newborn bovine serum, cell culture effect and fetal bovine serum similar to conventional cell culture, non-delicate cell culture, tumor cell culture and so on.
• This product is divided into two directions: cell culture and diagnostic reagents, with different purposes and production processes.

Veridated culturable cells:

HEK293,293T,Vero,CHO,LLC,Hela,MDCK,Hybridoma cells, and mouse Tlymphocytes etc.

Example of applicable cells:

Various tumor cell lines, epithelial cells, fibroblasts, genetically modified cells, alloploid cells, etc

• This is high grade FBS,
• Widely used in a variety of cell cultures, including some stem cells, primary cells and other delicate cells.
• Blood was collected from the heart of fetal bovine at 6-8 months of gestational age.
• C + A class purification workshop automatic filling line production, batch 4000 bottles, batch difference is very small.
• After 0.1micron 3 times sterilization filtration, comprehensive physicochemical, microbial detection.
• Very low endotoxin, no mycoplasma, and no specific antibodies.

Veridated culturable cells:

HEK293,293T,293E, Vero, CHO, LLC, Hela Renal epithelial cells, primary B lymphocytes, etc

There are two main models’ lines: benchtop Bio-Lab TFF for research and small-scale production and Bio-TFF skids for industrial scale.

Main features are:

• Hygienic design, compliant with GMP and ASME BPE requirements;
• Use sanitary grade peristaltic, quaternary diaphragm pump or rotor pump, low shear force, low pulse;
• Automatic TMP control, automatic concentration, equal volume filtration and other functions;
• Equipped with a built-in integrity detection module, without the need for an external integrity detector;
• English operating system, software complies with the requirements of FDA 21 CFR Part 11;
• Systems can be customized according to different technical requirements;
• Producer provides complete set of GMP verification documents and services

All the systems are customized and configured according to the customer’s needs and utilize the same software as non-disposable CIP/SIP down-stream equipment (complies with the requirements of FDA 21 CFR Part 11).

The pump heads, valves, probes (flow meters, pH, conductivity and UV detectors), tubing and other liquid contact components of single-use down-stream equipment are constructed as disposable replaceable parts, the “flow-path lines” are packaged aseptically in advance and installed directly after unpacking prior to use. 

Single-use design eliminates the needs of system cleaning between different batches and products and subsequent after-CIP validation; minimizes risk of cross-contamination; reduces facility area, production cycle time and cost; improves consistency and productivity for smaller scale facilities.

Hanbon provides FDA and USP VI certificates for non stainless steel materials in contact with the material liquid.

Newstyle laboratory liquid chromatography systems were developed for laboratory analysis, small-scale and pilot scale up. The infusion pump head and liquid circuit contact materials can be selected from SS316L, titanium alloy, PEEK etc., which are suitable for the special requirements of different customers’ processes. Dual wavelength UV visible detector, which can expand the detection range, and can also be equipped with differential refractive detector or evaporative luminescence detector.

CS-Prep industrial preparative HPLC systems include infusion, injection, detection, distillate collection, control and data processing modules. This model became the first diaphragm pump explosion-proof industrial preparation liquid chromatography system in China, which achieved balance, sample loading, flushing, elution, automatic collection, online cleaning and other process.

In 2005 Hanbon developed the first dynamic axial compression column with independent intellectual property rights in China, and by nowadays has built the largest dynamic axial compression column production and assembly workshop in the world. Dynamic axial compression columns are automated self-packed and unpacked in place devices, have pressure control system and can totally satisfy the continuity of the column bed, uniformity, stability, and tightness requirements, eliminate the influence of the column bed collapse.

Hanbon production facility is based on the design and implementation process of GAMP 5; producer provides complete GMP and FDA verification documents and services.

The control software is based on the secondary development of imported workstations and meets the requirements of FDA 21CFR Part 11.

Main features are:

• Imported Schott finished glass tube, easy to seal, high strength;
• Easy to Operate: The side sliding design of the column head eliminates the need for manual handling;
• Convenient Replacement: The sieve plate can be directly replaced at the bottom without disassembling the column barrel;
• Original Sealing Form: Original and highly reliable column head sealing form, manual sealing or automatic sealing; 
• Highly Capable: Reliable, convenient and safe operation
• Excellent Performance: The flow path has no dead zone design and excellent cleaning and verification performance; 
• Certified: The liquid receiving material is made of EU and US origin materials, totally complying with USP Class VI and FDA standards; 
• Documents & Services: Producer provides complete GMP verification documents and services.

All the devices come with verification documents that comply with GMP regulations.

Main features are:

• Key components of the system adopt internationally renowned brands, which are stable and reliable;
• The pipeline design adopts ASME BPE standard, with inner wall electric polishing, Ra ≤ 0.4um, and automatic welding;
• Provide FDA or USP Class VI material certification for non-stainless steel materials in contact with the sample;
• All stainless steel materials in contact with the sample have a serial number, serial number/furnace number to ensure traceability;
• The instrument adopts digital communication to overcome the problems caused by analog signals;
• HMI adopts self-developed software on the C # platform, which meets the requirements of FDA 21 CFR Part 11;
• Using a database to store data and having mature and reliable solutions to interface with various DCS systems;
• Provide complete GMP verification documents and services;
• Can achieve double-column position series-parallel connection.

Main features:

• Biocompatibility: stacked piping design, small dead volume, piping resistant to conventional organic solvents; 
• High flow accuracy: PEEK material dual pump head with high flow accuracy control and pump head self-cleaning function; 
• ​Multi user management: multi-user login and management, ensure information security and tracking;
• ​Custom method editing: process
• parameters setting module customization, process method self-editing;
• ​High degree of automation: low reagent loss, monitoring of synthesis pressure, conductivity and UV detection;
• High synthesis efficiency: > 99% for DNA, > 98% for RNA;
• Individually customized: base monomer and synthesis reagents channels quantity by customer’s needs;
• Compliance with laws and regulations: Software complies the regulations such as 21 CFR Part 11, explosion-proof design