Icluebio – Advena https://advena-bio.ae Thu, 19 Sep 2024 09:07:37 +0000 en-US hourly 1 https://wordpress.org/?v=6.8.1 https://advena-bio.ae/wp-content/uploads/2024/09/cropped-advena-favicon-32x32.webp Icluebio – Advena https://advena-bio.ae 32 32 iMSPR-mini SPR system https://advena-bio.ae/shop/protein-analysis-biotechnology/spr/imspr-mini-spr-system/ Fri, 13 Sep 2024 08:40:25 +0000 https://advena-bio.ae/?post_type=product&p=6255 Compact and easy to use SPR instrument for researchers, product developers, and medical sites.

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Compact sized, Incredible SPR system iMSPR mini

mini is SPR itself

mini is the basic model of iMSPR. Its optical platform is shared by all iMSPRs. All major parts are integrated into a small body.

Sustainable I-type fluidics module

Two different samples can be injected simultaneously with the I-type fluidics module. A completely different sample can be injected, and one channel can be used as a reference. In addition, since the I-type fluidics module is manufactured with a PEEK-based unibody, it can be used semi-permanently.

 

Inlet

Outlet

Wherever you want

The mini can be powered only with a mobile PC and USB connection. Feel free to use mini anywhere.

 

Whoever can access

mini is easy. The magnetic base allows the fluidics module to be easily combined with the prism holder, and the preparation is completed by inserting the prism holder combined with the main body.

 

Maximize through connection

Extreme flexibility

mini can connect with anything you can imagine. Challenge various applications by connecting to various devices based on 1/16 inch tubing.

iMSPR-mini standard

Standard mini models are supplied with an I-type fluidics module and tubing pump. It is possible to check the presence or absence of intermolecular bonds, to analyze approximate affinity and kinetics, and to conduct various application experiments.

 

For more accuracy

For more accurate kinetics evaluation, the experiment should be operated more stably. Try adding a degasser, injection valve, etc. for that purpose.

 

For high throughput

You may need to process a larger number of samples than you originally intended. Don’t buy a new device. By adding an autosampler to the mini, even a large number of samples can be processed.

 

iMSPR-Lab

The iMSPR-mini can be equipped with a variable angle module to study various films, various samples, various solvents…even gas sensors. Due to the variable angle module, the incident angle range is very wide from 40 degrees to 80 degrees. A wide angle of incidence range means no restrictions for your application.

 

Whatever, wherever you want

Diagnostic platform device

Develop a fluidics module according to your purpose. A mini can be a great sensor. mini will be a very suitable platform for diagnosing biomarkers in complex samples such as whole blood.

At physiological environment

Confirmation of binding properties at biological temperature can be of great importance. The mini fits in your own dryer and can be used up to 50 degrees Celsius.

 

In cooling chamber

Of course, the mini can do its part even in the cooling chamber.

 

On-site education

For student education, mini is a very suitable device. You can better understand the SPR phenomenon by directly adjusting the polarizer, and feel free to try the SPR device yourself.

]]> iMSPR-Pro SPR system https://advena-bio.ae/shop/protein-analysis-biotechnology/spr/imspr-pro-spr-system/ Wed, 11 Sep 2024 11:15:08 +0000 https://advena-bio.ae/?post_type=product&p=6126

Pro series common features

Sample to Answer

After designing an experiment through the Experiment Wizard, when a sample is injected, the kinetics evaluation value can be obtained through the automatic analysis function built into the iMSPR operating software.

Sustainable U-type fluidics module

Through the U-type fluidics module, the immobilization step can be shortened efficiently, and referencing can be performed perfectly without time lag. In addition, it can be used permanently since it is manufactured with a PEEK unibody.

 

Inlet 2

When using both channels (binding analysis)

Inlet 1

When immobilizing the ligand

Outlet

Automatic qualification check of sensor chip

The sensor chip status is checked before the experiment through the automatic check function built into the iMSPR operation software. You can secure more reliable data by checking initialization status.

 
 
 
 

In-line degassing system

If you use the iMSPR Pro series, degassing the buffer is unnecessary. The built-in degassing module reduces the failure rate of experiments by removing bubbles.

 
 
 

What are the differences between iMSPR Pro Series

.

Pro2X

ProX

Pro

Sample flow channel

4

two experiments per chip

4

one experiment per chip

2

one experiment per chip

Fluidics module

UFD Fluidics module with dual U-type flow cells

Standard Fluidics module with mono U-type flow cells

Standard Fluidics module with mono U-type flow cells

Sample injection

Autosampler with dual injection valve

48 vials rack x 2
96 well plate x 2

Autosampler with mono injection valve

48 vials rack x 2
96 well plate x 2

One by one

Sample volume (200ul sample loop)

Max 200ul Partial injection available 30 ~ 75 ul dead volume

Max 200ul Partial injection available 30 ~ 75 ul dead volume

Max 200ul Partial injection available 30 ~ 60 ul dead volume

Screening capacity

300 samples per day

150 samples per day

Not recommended

Add options, get powerful functions

Temperature control unit

In various temperature environments (10 to 40 degrees, room temperature dependent conditions), it is possible to obtain the value of the bonding properties and obtain the thermodynamic constants (enthalpy, entropy) through this. as well as biological temperatureThe binding properties of new drug candidates can be confirmed in the environment (37 degrees). Through this, predict the dynamics of the drug​ in the body and understand the bonding between molecules more completely.

Cooling unit

When a large amount of sample needs to be analyzed, drug candidates such as antibodies may be denatured due to the high temperature inside the autosampler. The cooling unit is a temperature cooling function inside the autosampler that can prevent this. It can cool down to 4 degrees, so you can safely analyze your samples until the end. 

GxP Program

21 CFR compliance compliant programs can be installed. 

Premium maintenance program

If you upgrade to iMcare+, a premium maintenance/management program, you can extend the warranty period to 2 years, as well as receive regular inspection, SW upgrade, free replacement of consumables and free operation training for 10 years.

 
]]> iMSPR Sensor Chips and reagents https://advena-bio.ae/shop/protein-analysis-biotechnology/spr/imspr-sensor-chips-and-reagents/ Wed, 11 Sep 2024 07:09:26 +0000 https://advena-bio.ae/?post_type=product&p=6076 The sensor chip surface must be selected correctly according to various conditions such as analyte type, analyte size, ligand immobilization method, and non-specific adsorption.

Alkanthiols based planar sensor chips

Since the iMSPR system has sufficient sensitivity, satisfactory results can be obtained even on a sensor chip (Planar Au sensor chip) formed with a monolayer of linker material that can immobilize the ligand in the case of a molecule with a relatively large size (about 5 kDa or more) – protein, cell, bacteria, virus, exosome, etc. In particular, in the case of antibody drugs, it is a very suitable application field because the signal is large and the affinity is high.

Structure

 

Immobilization level (Max.)

100 ~ 2000 RU (molecule type and MW dependent)

Dextran based membrane sensor chips

Dextran sensor chips were first commercially available in the early 1990s by applying solid surface technology well-optimized for affinity chromatography. Therefore, the largest amount of data has been accumulated using SPR to date. Therefore, there are many literatures and results that can be referenced, which is very advantageous for reproducing similar experiments. It is a universal sensor chip that can be used from large-sized proteins to small compounds.

Structure

 

 

Immobilization level (Max.)

1000 ~ 10000 RU (molecule type and MW dependent)

Linear polymer based membrane sensor chips

The linear polymer sensor chip developed this time is a sensor chip that complements the shortcomings of the dextran sensor chip while maintaining the performance of the membrane sensor chip. It can be fabricated more reproducibly, exhibits a higher signal-to-noise ratio, improves diffusion properties and reduces non-specific adsorption. A representative sensor chip is the HC1000. It is a sensor chip suitable for analyzing small molecular compounds.

Structure

 

Immobilization level (Max.)

1000 ~ 20000 RU (molecule type and MW dependent)

Contact angle comparison

Sensor chips have different degrees of hydrophilicity depending on the backborn material structure. Instead of using just one chip, improve the quality of your analysis with sensor chips of various surfaces.

Sensor chip storage kit

It is an essential tool to keep your sensor chip running. After removing the used prism holder from the device, install the s-type fluidics module. Then fill with storage buffer and store in the refrigerator. The ligand material immobilized on the sensor chip can be safely stored until the next use.

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