Live cell imaging is particularly well-supported by the CELENA® S, which offers a dedicated time-lapse mode for observing live cells in a controlled environment. This mode allows researchers to monitor cellular processes over time and generate time-lapse videos complete with annotations. The system’s onboard data analysis tools enable users to measure and annotate images directly, with data easily saved either to the system’s onboard storage or exported via a USB drive. For detailed imaging of cellular structures, the CELENA® S provides Z-stack imaging capabilities, allowing users to capture multiple focal planes and either stack them into a single composite image or compile them into a video for comprehensive analysis.

The CELENA® S is highly versatile and customizable, accommodating a wide range of imaging needs. It features an onstage incubation system that maintains precise control over the imaging environment, including temperature, humidity, and gas composition. The temperature controller separately heats the plate and lid of the stage incubator to prevent condensation and ensure accurate temperature regulation. Additionally, the CELENA® S offers a selection of interchangeable filter cubes and objectives, including over twelve hard-coated LED fluorescence filters and infinity-corrected objectives with magnifications ranging from 1.25X to 100X. A range of vessel holders and LED filter cube options are available to tailor the system to specific experimental needs, making the CELENA® S an adaptable and powerful tool for diverse cell imaging applications.

The CELENA® X excels in fully automated plate and slide imaging, featuring automated vessel handling and scanning through a motorized XYZ stage, filter cube stage, and objective turret. Its laser autofocus ensures rapid, reproducible focusing while minimizing phototoxicity and photobleaching, which is crucial for maintaining cell viability during imaging. For live cell assays, the onstage incubation system provides precise control over physiological and non-physiological conditions, supporting a variety of experimental setups. The system supports four imaging modes: fluorescence in four channels, brightfield, color brightfield, and phase contrast, accommodating diverse imaging needs and experimental requirements.

The CELENA® X’s powerful and user-friendly software interface simplifies the setup of imaging protocols and integrates seamlessly with data analysis processes. Its customizable high content analysis capabilities allow for the creation of tailored workflows that can handle both straightforward fixed cell assays and complex, time-lapse live cell assays. The system supports a wide array of applications, including cell counting, cytotoxicity assays, transfection efficiency, wound healing, apoptosis, confluency, calcium signaling, phagocytosis, cell cycle analysis, stitching, and 3D cell modeling. The CELENA® X is designed to be versatile and adaptable, with comprehensive vessel holder options, objective selection guides, and LED filter cube guides available to ensure that the system meets all of your cell imaging needs.